Optic Nerve Hypoplasia – American Association for Pediatric Ophthalmology and Strabismus

Allan I. Fleming

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What is the optic nerve?

The optic nerve is a assortment of additional than a million nerve fibers that transmit visible signals from the eye to the mind [See Determine 1]. The optic nerve develops for the duration of the initial trimester of intrauterine lifestyle.

Fig. 1: Ordinary optic nerve.

What is optic nerve hypoplasia?

Optic nerve hypoplasia (ONH) is a congenital ailment in which the optic nerve is underdeveloped (small) [See figure two].

Optic nerve hypoplasia

Fig. two: Optic nerve hypoplasia.

How is optic nerve hypoplasia diagnosed?

The analysis of ONH is typically made by the visual appeal of small/pale optic nerve for the duration of a dilated eye exam. It is hard to predict visible acuity probable dependent on the optic nerve visual appeal.

What brings about optic nerve hypoplasia?

Most circumstances of ONH have no clearly identifiable bring about. There are no acknowledged racial or socioeconomic elements in the advancement of ONH, nor is there a acknowledged association with exposure to pesticides. ONH has been connected with maternal ingestion of phenytoin, quinine, and LSD, as well as with fetal alcoholic beverages syndrome.

What visible issues are connected with optic nerve hypoplasia?

Eyesight impairment from ONH ranges from gentle to critical and may well influence one or the two eyes. Nystagmus (shaking of the eyes) may well be witnessed with the two unilateral and bilateral circumstances. The incidence of strabismus is amplified with ONH.

Is optic nerve hypoplasia connected with non-visible issues?

Optic nerve hypoplasia can be connected with central nervous system (CNS) malformations which set the client at possibility for other issues, including seizure dysfunction and developmental delay. Hormone deficiencies come about in most little ones, irrespective of connected midline mind abnormalities or pituitary gland abnormalities on MRI. In fact, most little ones with progress hormone deficiency have a regular MRI.

What checks ought to be completed for little ones with optic nerve hypoplasia?

An MRI scan is indicated for all little ones with optic nerve hypoplasia. Analysis by an endocrinologist ought to be necessary for all people beneath 5 a long time of age.

Does optic nerve hypoplasia get even worse around time?

In common, ONH is a steady and nonprogressive ailment which does not deteriorate. Eyesight may well boost slightly and nystagmus may well decrease around time.

Is there any therapy for optic nerve hypoplasia?

There is no health-related or surgical therapy for ONH. Even so, occlusion of the much better seeing eye may well boost vision in the other eye. Small children with substantial vision loss in the two eyes may well profit from early supportive notice by low vision specialists. Stem mobile therapy has not been demonstrated to be successful for ONH.

Exactly where can I discover additional details relating to septo-optic dysplasia?

Inbound links to Content on Stem Mobile Remedy for Optic Nerve Hypoplasia and Other Brain Problems

  • Fink C, Garcia-Filion P, Borchert M. “Failure of stem mobile remedy to boost visible acuity in little ones with optic nerve hypoplasia.” J AAPOS. 2013 Oct seventeen (5):490-3. St. Louis Children’s Clinic Push Launch, February 18, 2008, “Stem mobile therapy for little ones with eye nerve illness known as ‘medical hoax’”. 
  • Ophthalmology Occasions, September 1, 2008 issue, Industry News, “Parents warned about ‘medical hoax’ encompassing optic nerve hypoplasia. (Ophthalmology Occasions E-News, August 1, 2008).
  • EyeWorld, January 2009, Sounding the alarm, stem mobile therapy fraud. Maxine Lipner, Senior EyeWorld Contributing Editor.
  • 60 Minutes, September 15, 2010, “21st Century Snake Oil”. (Marketing consultant) 
  • Tychsen L, Lueder G, Stahl, E, Giangiacomo J: Stem mobile remedy does not boost visible function or framework in little ones with optic nerve hypoplasia (septo-optic dysplasia). 2010 AAPOS Summary #034. J AAPOS 201014(1) e9.

Current 09/2019


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